YK11 was first studied in 2011 by Japanese researcher Yuihi Kanno. YK11 attaches to androgen receptors and helps inhibit myostatin production in muscles, allowing them to produce more FST and thus grow muscle.

The effect of myostatin on muscles

There are two proteins known to control muscle size and quantity: Myostatin and Activin A

Myostatin, a protein naturally produced by the body, limits muscle size. Activin A limits muscle differentiation to increase number.

Myostatin is a member of the transforming growth factor-β superfamily.

Originally discovered in 1997 by biogeneticists, they found that mice lacking the code for myostatin had roughly twice the size of normal mice. Later, natural deficiencies in various types of myostatin were found in some breeds of cattle, sheep, and humans, in each case the result was a dramatic increase in muscle mass, leading to the discovery of the role of myostatin in muscle. The relationship between - myostatin prevents muscle growth.

What is Myostatin？

Myostatin is also known as GDF8(growth Differentiation factor 8). In a 1997 experimental report, Mcpherron et al. demonstrated the biological effects of targeted disruption of the mouse growth and differentiation factor 8(GDF8) gene. Mice deficient in GDF8 had significantly larger body size than wild-type mice and generally increased skeletal muscle mass. The weight of single muscle in mice lacking GDF8 gene expression is 2-3 times that of wild mice, and the increase of muscle mass is the result of muscle hypertrophy and hyperplasia. These experiments established that GDF8 peptide is the main participant in inhibiting muscle growth, which was named Myostain. So myostatin is also known as GDF8.

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