SARM LGD4033 Muscle Building History

LGD-4033 was described in 2007 by the US biotech company Ligand Pharmaceuticals (so LGD4033 is also known as Ligandrol) and is currently being developed by Viking Therapeutics under the code name VK5211, originally developed for the treatment of muscle wasting and osteoporosis Because of its effect on a specific androgen receptor, it can improve the user's muscle mass and bone density, so it is welcomed by the majority of bodybuilders and is widely used in the field of bodybuilding.

Clinical study of SARM LGD4033 Muscle Building

Before any drug is put on the market, a lot of clinical research must be carried out. Clinical research includes many stages. Through the research on drug safety, pharmacokinetics and effects, the efficacy and safety of the drug are determined. Since its discovery, LGD4033 has undergone two phases of clinical research.

In a Phase 1 clinical study, investigators focused on the safety, pharmacokinetics and effects of LGD4033 in healthy men

In this study, 76 healthy men (21-50 years old) were randomly assigned to placebo or 0.1, 0.3 or 1.0 mg LGD-4033 daily for 21 days. Blood counts, chemistry, lipids, prostate-specific antigen, electrocardiogram, hormones, lean and fat mass, and muscle strength were measured during and 5 weeks after the intervention.

From this study, the researchers concluded that LGD-4033 is safe, has a favorable pharmacokinetic profile, and increased lean body mass without changes in PSA even during this short period of time.

On November 3, 2015, in a phase 2 clinical study, the researchers tested 120 patients after hip fracture surgery. The subjects were divided into a placebo group and different doses of LGD4033 over a 12-week test period. .By observing the changes of the subjects' net body weight, quality of life, safety and pharmacokinetics.

Through this clinical trial, LGD4033's ability to stimulate and maintain lean body mass, improve muscle strength and improve bone mineral density is beneficial in older adults who are most at risk for and at risk for hip fractures.

From the above studies, it can be seen that LGD4033 has good effects in terms of safety and pharmacokinetics, can increase and maintain lean body mass, improve muscle strength and improve bone mineral density. This is very beneficial for Bodybuilders in the bodybuilding process.

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